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(2014) published foundational work demonstrating that NNMT expression in adipose tissue correlates with metabolic parameters in preclinical models

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The conclusion is that B vitamins can be used in treating neuroinflammation and promoting neuroregeneration, potentially serving as an effective therapy for PNI in humans.

Liver enzyme monitoring typically occurs at regular intervals, every 3-6 months during the first year of treatment, then annually if stable