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Funding This work was supported by: open access funding provided by the: National Plan for NRRP Complementary Investments (PNC, established with the decree-law 6 May 2021, n

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GLP-1R action on neuroprotection GLP-1R analogs have neuroprotective and anti-inflammatory properties, which may be contributing the beneficial effects on energy metabolism (reviewed in Holscher, 2014)

Thigh : Upper portion of the thigh, between the front and outer areas

We obtained the entries for the responsible metabolic enzymes from the BRaunschweig ENzyme DAtabase (BRENDA) database 81 and extracted their allosteric effector (activator and inhibitor) information and inhibitory half-saturation constants (K i ) values, as reported for Homo sapiens , Mus musculus , and Rattus norvegicus