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The DAC (Drug Affinity Complex) modification increases half-life substantially

The biomimetic nanodelivery systems (BNDSs) were developed more recently and exhibit the advantages of inherent natural biocompatibility, low immunogenicity, and promising potential due to the fact that they are made directly from cell membranes (normal or diseased cells) or by coating nanoparticle surface with cell membranes [11]

APT2 depalmitoylates GSDMD-NT at the membrane to reveal Cys192 residues, thereby promoting GSDMD-NT oligomerization and pyroptosis (78)

This combination works beautifully for improving fine lines, dullness, and overall radiance