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Week 3-4 (or 5-8): If well-tolerated without adequate response, increase to 300mcg nightly
The dose escalation schedule spans 16 to 20 weeks: 0.25 mg for four weeks, 0.5 mg for four weeks, 1.0 mg for four weeks, 1.7 mg for four weeks, and finally 2.4 mg as the maintenance dose
Immune response may also generate autoantibodies that interfere with cardiac ion channels, further destabilising electrical activity (91, 92)
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Dose for Regular Users Regular users may increase their Trulicity dose if additional glycemic control is neededthis is done in 1.5 mg increments after receiving their current dosage for at least 4 weeks, up to a maximum of 4.5 mg once per week
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