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The GLP-1R is also expressed in DRG neurons and sensory innervation of the gut in mice, providing a signalling route to the CNS following activation by distally released GLP-1 via local and spinal sensory nerves [31, 32], and mediates neurite outgrowth after GLP-1 and exendin-4 treatment [32]
However, using semaglutide to suppress appetite and manage weight is usually a longer-term treatment
Lower doses remain effective for those who cannot tolerate maximum dosing
Facial rejuvenation after GLP-1 weight loss is highly individualised
Because it contains fish-derived proteins, it's not suitable for all diets
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