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Rapid weight loss can cause an aged appearance mostly because patients lose the fat pads characteristic of youthful facial contours, says Jessica Weiser, MD, a board-certified dermatologist and founder of Weiser SkinMD with locations in NYC and Aspen

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10.1016/j.cocis.2020.101413 Curr Opin Colloid Int Sci

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A 2017 review summarised neuroprotective properties of silymarin in animal models, including: Reduction of amyloidogenic activity (relevant in Alzheimer's research) Anti-inflammatory action in nerve tissue Reduction of oxidative stress in the brain Possible positive effects on cognitive function Possible reduction of stroke risk Whether these effects can be achieved in humans at attainable concentrations of silymarin in particular whether sufficient quantities can cross the blood-brain barrier remains unclear

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