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found that 4-HNE, a toxic product of lipid peroxidation, serves as a potential mediator linking ferroptosis and inflammation in FRDA fibroblasts (390)

The study was conducted by Dr Marcel Muskiet of Leiden University Medical Center in the Netherlands, Professor David Cherney of the University Health Network and the University of Toronto in Canada and colleagues

Advice for Healthcare Professionals The MHRA has advised that healthcare professionals remain vigilant for symptoms of acute pancreatitis, which may be challenging to recognise in early stages, and use GLP-1/GIP receptor agonists and GLP-1RAs with caution in patients with a history of pancreatitis

Methods Materials All the chemicals were purchased from Sigma-Aldrich or Alfa Aesar unless otherwise specified

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