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Moreover, they revealed that the mechanism by which RSV enhances the GSH system involves the AMPK signaling pathway, the Nrf2 signaling pathway, the Sirt1 pathway, noncoding RNA (miR-149) and the KAT5 gene [193,194,195,196,197]
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Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production (Statzer et al., 2022)
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