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Guidelines for investigations and treatment of iron levels are in development
Mechanistic studies showed that GPX4 expression and ferrous iron were increased in 5-FU and AZ628-derived CRC persister cells, residual subcutaneous transplantation tumors, and colorectal cancer patients undergoing neoadjuvant chemoradiotherapy
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Similarly, diets excluding animal products are becoming more popular worldwide, and if not properly planned and well balanced do not provide enough iodine, often requiring supplementation [34]
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