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TB-500 has a distinct amino acid segment [(17)LKKTETQ(23)] which is hypothesized to be responsible for actin binding and potentially enhancing cellular motility

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For example, some studies reported an average weight loss of 5.4% to 8.1% of starting body weight with Contrave, versus 1.3% to 4.9% with placebo

More provocative is that the directionality of the variants effect reported in the Nature paper is the opposite of these previous studies