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Consistently, cells expressing WT or S1025D exhibited more continuous and organized Golgi ribbon structures, whereas S1025A expression resulted in fragmented and disorganized Golgi morphology (Figure 4F, G)

However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects

Given that the sale of these medications spans various risk types, agents must be prepared to collaborate with wholesalers who can swiftly locate suitable coverage, whether by moving the entire risk or developing a carve-out policy

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