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In the AMPLITUDE-O post-hoc analysis, the HR for MACE was 0.70 (95% CI 0.371.30) with baseline SGLT2is and 0.74 (95% CI 0.580.94) without SGLT2is ( P -value for interaction 0.70), and the HR for HHF was 0.23 (95% CI 0.050.97) with SGLT2is and 0.70 (95% CI 0.421.17) without SGLT2is ( P -value for interaction 0.35) [47]
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MOTSc: Mitochondriaderived peptide with AMPK activation and insulin sensitivity effects
For meaningful assessment of treatment response, standardized measurements should be employed, including limb circumference at defined anatomical points, validated pain scales, and quality-of-life instruments specific to lipedema or lymphatic conditions
Abbreviations DPP-4: Dipeptidyl peptidase-4 EMA: European Medicines Agency EPAC: Exchange protein directly activated by cAMP FDA: Food and Drug Administration FGF21: Fibroblast growth factor 21 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 PKA: Protein kinase A SGLT-2: Sodiumglucose cotransporter 2 References Moore B, Edie ES, Abram JS (1906) On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
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