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Poster presented at the International Diabetes Federation Congress, 26 December 2019, Busan, Korea
FIGURE 2 HSP70 and HSP90 act as sensors and play crucial roles during the sensing phase
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This could be because tirzepatide works through a dual mechanism targeting both GLP-1 and GIP receptors
Importantly, if L-carnitine supplementation is to be used as a tool to modify skeletal muscle energy metabolism, the findings in the 14 day study also suggest that, at most, only two 500-ml CHO drinks (2 x 94 g CHO) are required to achieve the effect on L-carnitine retention. In conclusion: muscle free carnitine availability becomes limiting to carnitine palmitoyltransferase I (CPT1) at a concentration of about 6 mmol/kg dry muscle
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