[5] Specifically, it reduces not just body weight but importantly waist circumference
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Common side effects of orforglipron include: Nausea (feeling sick) Vomiting (being sick) Diarrhoea and/or constipation Indigestion, stomach pain, gas or bloating Headaches Fatigue (extreme tiredness that doesnt improve with rest) Temporary hair loss You can help manage any side effects by: Eating small amounts of plain food frequently throughout the day Getting enough sleep (seven to nine hours a night for most people) Drinking plenty of water to prevent dehydration (At least 1.5 to 2 litres per day, more if you have vomiting or diarrhoea) Gradually increasing your fibre intake and taking regular exercise to prevent constipation Taking over-the-counter painkillers like paracetamol to treat headaches or stomach pain Taking a vitamin or supplement to help with issues like hair loss and fatigue
J Am Board Fam Med
GLP-1 RAs, such as semaglutide and tirzepatide, may also help improve metabolic health in patients with PCOS by promoting weight loss, improving insulin sensitivity, and reducing blood glucose levels ( 4 , 6 , 14 )