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The GCGR component is specifically hypothesised to contribute via cyclic AMP-mediated beta-oxidation pathways in hepatocytes, though this mechanistic attribution requires further controlled validation [VERIFY]
Briefly, a gross evaluation was conducted when possible, tissues were infiltrated with paraffin, and hematoxylin-and eosin (H&E) staining was performed
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This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]
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