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PLOS ONE 8 , e61053 (2013)

Translating to humans, experts cautiously estimate a 26 hour half-life when given subcutaneously

Most concerns about supplement-drug interactions center on oral medications, enzyme inhibition (cytochrome P450 interactions), or nutrient binding

The Impact of a Single Day on Symptoms and the Misconception of B12 Storage B12 Excretion: You are correct that a significant portion of the injected hydroxocobalamin is excreted from the body within 48 hours

Albumin and IgG can be taken up by endothelial cells lining blood vessels by fluid-phase pinocytosis and enter the endosomal pathway