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Moreover, 3,4,5-tri- O -caffeoylquinic acid has been shown to enhance pigmentation during the anagen phase of the hair cycle in C3H mice, and human epidermal melanocytes and B16F10 murine melanoma cells by up-regulating the expression of -catenin
On the other hand, DSIP and CBBBP show no improvement when compared with the model group (Figure 8A)
Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms
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