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Post-weight-loss hormonal adaptations exacerbate challenges, with decreases in anorexigenic hormones and increases in orexigenic ones driving weight regain (10)

In another randomized controlled trial in overweight adults with evidence of pre-existing vascular dysfunction, 450 mg per day of a hesperidin supplement for six weeks resulted in lower blood pressure and a decrease in markers of vascular inflammation (Salden 2016)

Exercise preserves lean mass when weight fluctuates on GLP-1 therapy and can reduce pain