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The pathogenesis of RIP involves multiple pathological processes, including radiation-induced excessive production of reactive oxygen species (ROS), leading to oxidative stress, which in turn triggers apoptosis and mucosal barrier disruption, as well as an inflammatory cascade centered on proinflammatory cytokines
PMID: 39068812
This fibrous of thyroid atrophy progresses into a aggressive form as people age, so patients need urgent thyroid hormone replacement after diagnosis
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& Pendergast, J
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