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Medicare Part D plans are required to cover at least two drugs per class, so once a generic is available, your plan might move the brand-name version to a higher tier or require step therapy (try the generic first)
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The dosage is started at lower doses and increased gradually to prevent the risk of side effects
The Trp and Phe residues in the pharmacophore of both MT1 and MT2 (the His-Phe-Arg-Trp core sequence) are vulnerable to reactive oxygen species
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