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Studies have found for example that simvastatin inhibits the proliferation, invasion, and migration of the ovarian cancer cell lines OVCAR3 and SKOV3, thereby possibly exhibiting anti-metastatic effects also in ovarian cancer in vivo [88, 89]
Grabbe S, et al
So basically, everything surrounding obesity-related heart failure with preserved ejection fraction was improved with active therapy. No Effect on Other Heart Measurements While the reduction in LV mass and fat was significant, tirzepatide didnt affect: LV end-systolic volume LV function Left atrial (LA) volumes and function In another recent study, the SELECT trial, the GLP-1 semaglutide did show an impact on LA volumes and other markers of heart function, but no effect on LV mass
(Recent studies support this, too.) Metformin, another diabetes medication, has already been shown to have this effect in women with PCOS, so it isnt surprising that GLP-1 RAs would have this effect, she adds
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