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Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N(1)-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells
Like any prescription medication, these drugs can cause side effects
The MHRA advises patients on all GLP-1s to use contraception while taking GLP-1 medicines (including an additional barrier method for patients starting or increasing tirzepatide who are using oral contraception), as well as for a defined wash-out period afterwards before trying to get pregnant (see Figure 3)
Appropriate supplementation, when indicated based on individual assessment rather than routine use, can help address nutritional gaps during tirzepatide therapy
Endocrinology 149 , 56795687, (2008)
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