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471 Knocking down FTH in cardiomyocytes prevents free iron from being stored in ferritin, increases unstable iron pools, promotes intracellular ROS production, activates oxidative stress, and causes ferroptosis in cardiomyocytes, leading to age-related heart damage

Ferritinophagy is a key mechanism for rapidly increasing the iron content of the LIP when needed and is important for increasing cellular sensitivity to ferroptosis (25)

AICAR is itself a potent AMPK activator, the same intermediate compound that the pharmaceutical agent AICAR infusion uses to mimic exercise in rodent studies

Sekhar, Rajagopal V., et al

NMR resonance assignments of FAT were taken from prior experiments 51 (BMRB 28012) and matched with identical buffer conditions