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One of the few reports to support this supposition was the measurement of portal venous endotoxin concentrations and culturable bacteria in patients undergoing elective laparotomy [59]

While it is naturally found in the body, levels can be reduced by factors such as age, stress, and poor nutrition

doi:10.1016/S0140-6736(99)80019-1

Annu Rev Pathol 2014

Central venous access is preferred for cumulative dosing above 20 g to avoid phlebitis, and continuous electrocardiography, non-invasive blood-pressure, and pulse-oximetry are minimum monitoring standards throughout and for at least 30 minutes after infusion