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Absorbing vitamin B12 requires the secretion from the Intrinsic factor which is a glycoprotein produced by the parietal cells in the stomach

This strict protocol is critical because globally, 10-15% of untreated cases lead to neuropathy within just six months

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Pharmacokinetic studies have shown that even with oral doses as high as 8,00012,000 mg/day, curcumin remains undetectable in systemic circulation or is only present at nanomolar levels, while its metabolites appear in trace amounts (178180)

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