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In selected cases where a sulphonamide is clinically essential, specialist allergy services may consider graded challenge or desensitisation under close supervision

However, like any intravenous treatment, it carries minor risks, including: Temporary nausea or dizziness Allergic reactions (rare) Skin rashes Mild pain at injection site Dr

Third, as we will detail below (see Potential Pathogenic Mechanisms of Hyperhomocysteinemia), our own work (Durand et al, 1997a) and the work of Lentz et al (1996) and Bellamy et al (1998) give experimental evidence that moderate hyperhomocysteinemia, which leads to vascular dysfunction, might increase the cardiovascular risk independently of other risk factors