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Cellular energy & mitochondrial function studies
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At peripheral levels, the administration of GLP-1 RA regulates follicular proliferation and apoptosis-induced follicular atresia of the granulosa cells, a key component of the dominant follicle selection, possibly contributing to the oocyte maturation in PCOS
To quantitatively compare the metabolic and functional capacity of type I and II enterocytes, metabolic module scores were calculated by averaging the expression of functional genes involved in fatty acid transport and processing, digestive enzymes, cholesterol transporters, amino acid transporters, cell junctions, inorganic solute transporters, and organic transporters, respectively (Supplementary Fig
The LEADER trial (liraglutide) and SUSTAIN-6 trial (semaglutide) demonstrated cardiovascular risk reduction over multi-year follow-up periods (approximately 3.8 years and 2.1 years, respectively)
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