Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice
Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism
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10.3390/biomass5020025 98 MaurcioT.CoutoD.LopesD.CondeT.PaisR.BatistaJ.et al