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Relevance of the p53-MDM2 axis to aging
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for type 2 diabetes management, though some specific formulations are now licensed for weight management in adults with obesity or overweight with weight-related comorbidities
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Several case series (60) suggest that the combination of a better glycemic control, improved metabolic parameters and bodyweight reductions achieved by exenatide treatment as monotherapy or as add-on to standard therapies may lead to improvements in liver biomarkers and hepatic fat reductions in patients with T2D
[5] These results are consistent with those of the larger HPS2-THRIVE trial in which the addition of extended-release niacin to effective statin-based therapy did not result in a greater reduction in the incidence of cardiovascular events
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