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In the interim analysis of a phase III study (REGENERATE trial) at 18 months, 931 NASH patients with stage 23 fibrosis were randomly assigned to placebo and showed significant fibrosis improvement without NASH deterioration
They are a component of the cell membrane which surrounds and protects the cell, supporting interactions between cells
Treatment with HRS9531 resulted in robust improvement in cardiometabolic risk factors including blood pressure, lipids, measures of insulin resistance and hsCRP (high sensitivity C reactive protein)
Ferroptosis has been implicated in the pathophysiology of stroke, traumatic brain injury, and major neurodegenerative diseases such as Alzheimers disease (AD), Parkinsons disease (PD), and Huntingtons disease (HD)
The MHRA approved Wegovy in 2023 following clinical trials demonstrating significant weight reduction when combined with lifestyle modifications
