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Cyclisation restricts backbone conformational freedom and confers marked resistance to proteolysis relative to linear analogues, which is why melanotan 2 became a standard reference agonist rather than a research curiosity
DEgidio F, Castelli V, Lombardozzi G, et al
Its dragging yourself to the grocery store and spending a fortune on foods that make you want to gagall because some diet guru says they're "good for you." No thanks
In Parkinsons research, a randomized trial of exenatide showed slowed motor deterioration after 48 weeks compared to placebo
This framing can deepen weight stigma and perpetuate harm, especially to those in larger bodies
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