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120 However, the only clinical study with MMP inhibitor (PG-116800) for OA treatment resulted in termination due to musculoskeletal toxicity without clear benefit, suggesting more preclinical studies are needed to fully assess the safety and effectiveness of those matrix degradation inhibitors, and devise ways to improve efficacy
Dutton JJ
For example, the conversion of phenacetin into acetaminophen (Figure 6)
Some researchers find they never need to return to their pre-break dose
Basic Clin Pharmacol Toxicol 136(3): e70004
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