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Metformin-Induced Vitamin B12 Deficiency in Patients With Type-2 Diabetes Mellitus
Standard oral protocol: Dose: 500 mcg per capsule Frequency: Once daily Timing: On an empty stomach, 30 minutes before food Duration: 4 to 8 weeks Cycle recommendation: 2 months on, 2 months off Taking the capsule on an empty stomach maximizes absorption by reducing competition with food proteins for intestinal transport
\Obesity Prevention: Improves energy expenditure and glucose utilization (PMC Review, 2022)
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