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Patients should never adjust or discontinue either antidepressants or GLP-1 medications without explicit guidance from their treating physicians, as abrupt changes can trigger depression relapse or rebound appetite issues

46 There is a relationship between HFpEF and obesity, with the latter considered not only a significant comorbidity but also a direct contributor to HFpEF

Variations in your GLP-1 receptor gene (GLP1R rs6923761) and other peptide-pathway markers influence how your body responds to tirzepatide dosing and metabolic changes

Vitamin B12 is particularly important to monitor, as metformin is known to impair B12 absorption

Case studies will showcase the characterization of GLP-1 analogsincluding liraglutide, semaglutide, and related peptideshighlighting applications such as aggregation screening, impurity profiling, and stability analysis