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It may also be responsible for toxicity and liver failure seen at lower doses (Amar 2007)

See Pros and Cons of Using PRP for Tendon Injuries Prolotherapy This treatment involves administering small amounts of a medicated solution, such as dextrose or saline, into the rotator cuff tissue(s) over a period of several weeks with the goal of inducing tissue regeneration, promoting healing, and reducing pain

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This condition is called megaloblastic anemia