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[Abstract] Proc Natl Acad Sci U S A
H.BahariZ.JangraviZ.ImanM
A physician-directed protocol typically moves through these stages: GHK-Cu works through cumulative collagen synthesis and gene expression changes, not surface-level effects
By suppressing tyrosinase activity, it shifts melanin production from eumelanin (dark, brown pigment) toward phaeomelanin (lighter pigment), progressively reducing skin darkness and evening out tone across treatment cycles
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