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If you have nonalcoholic fatty liver disease (NAFLD) or mild kidney impairment, semaglutide may help improve these conditions through weight loss and glycemic control

It upregulates genes involved in repair, antioxidant defense, and stem cell function while downregulating genes associated with inflammation, fibrosis, and tissue destruction

Dose adjustments should aim for the lowest appropriate dose to limit side effects and improve adherence

Patients on the 12mg weekly dose lost an average of 24.2% of body weight over 48 weeks

An additional efficacy measure, objective response rate, was also statistically different, with 41% of patients receiving Ogsiveo seeing a response versus just 8% of those on placebo