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The relationship between copper chelating activity and tyrosinase inhibition is well established (Jung et al., 2024)

Autophagy 15(1):131150 Yildirim Simsir I, Cetinkalp S, Kabalak T (2020) Review of factors contributing to nodular goiter and thyroid carcinoma

Answer: Reported tolerability of these peptides is generally favorable in the literature, but they are not FDA-approved drugs, long-term human safety data is limited, and use should always be medically supervised