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A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists as a class were associated with increased biliary disease risk

Of interest, in the group of streptozocin-induced diabetic rats, the treatment with Ex4 reduced inflammation and fibrosis both in the ovary and endometrium, with associated decrease in inflammatory and oxidative stress markers, and increased ovarian reserve

Give those changes time to play out before concluding the dose needs to change

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In contrast, approximately 92% and 87% of D-CuP remained unchanged after 0.5 and 4 h of protease K exposure, highlighting its superior protease stability