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This is especially important for people with diabetes who are already on GLP-1 medication therapy , as combining berberine with GLP-1 agonists could potentially cause additive blood sugar reduction

The primary contraindication is a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

What constitutes unresponsive: Clinically, per manufacture, a patient should not be considered as unresponsive to therapy until less than 5% weight loss over the course of 3 months of Semaglutide at 2.4 mg=100 units/wk has been established

Failure to treat Peritonitis Any delay or failure to treat peritonitis can lead to sepsis

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