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As the substituents are ortho,para-directing and para with respect to each other, all positions on the ring are more or less equally activated
doi: 10.1111/obr.13929, 7 Bernosky-SmithK
For BPC-157, cycling protocols serve two purposes: preventing potential receptor downregulation or tachyphylaxis, and avoiding any theoretical long-term risks associated with sustained peptide signaling
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