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The goal is to maintain a steady level of pain relief so you never hit that painful crash. By alternating the medications every 3 hours (each individual drug taken every 6 hours), you make sure that as one medication dips, the other is reaching its peak
I generally recommend starting with the lower dose of 0.25 mg for the first week before considering increases
22 : 540544 Jope RS
Kannt A et al
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