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To address the major differences in glutaredoxin activities, we previously suggested two nonexclusive working models for glutaredoxin catalysis termed glutathione scaffold and glutathione activator model

Mitochondria generate the majority of cellular ROS as a byproduct of oxidative phosphorylation, and mitochondrial GSH is the primary defense against this constant oxidative burden

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In standard 7H9 media vadK , vadK:vadK His422Ala , vadK:vadK His422Asp and vadK:vadK Arg106Lys Mtb strains grew slower than the parental and complemented strains, but after 21 days incubation, there was no significant differences between the strains (Appendix Fig

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