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The predominance of observational studies indicates a significant gap in high-quality RCTs

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[21] [22] Finally, the psychological and physical stress of adapting to new medication, managing side effects, and experiencing body composition changes may independently trigger telogen effluvium in susceptible individuals

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Background on Weight Loss Medications Under CMS For two decades, Medicare Part D has prohibited coverage of weight-loss drugs, largely because of legitimate safety concerns at the time (think fen-phen)