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For instance, a study in rats suggests that melatonin may counteract tau pathology by upregulating the activity of phosphatase 2A [114], an enzyme recognized for its role in dephosphorylating microtubule-associated protein tau [124]

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These individuals were thought to harbor an abnormality in the enzyme, transketolase

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These individuals often show blunted GLP-1 responses after meals, suggesting that improving baseline metabolic health can restore more robust GLP-1 signaling over time (Huber et al., 2024)