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People who were carnitine-deficient or had low stores (older adults, some clinical groups) show larger and faster effects than well-fed young athletes whose muscle stores are already near capacity
Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency
An estimated 20% of obese patients have minimal or no response to GLP-1s and around 40% stop treatment after 12 months mostly due to shortages, dosage inconvenience3 and costs
Navigating Digestive Side Effects with Confidence Its important to remember that for most patients, these tirzepatide gut effects and semaglutide digestion issues are manageable, particularly as your body adjusts to the medication and the dosage is carefully titrated
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