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Brain Behav Immun 50:101114

FIGURE 25 FIGURE 26 FIGURE 27 SAR studies contributed to the design of 35 novel dual inhibitors, among which four compounds, compounds 87 (compound 18) , 88 (compound 19) , 89 (compound 20) , and 90 (compound 21) exhibited comparable binding affinities to PDE1/10A

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SURMOUNT-1 enrolled adults with obesity or overweight with weight-related comorbidities, demonstrating that dual agonism could achieve weight loss results that approach those seen with bariatric surgery

Bypasses Regulation: Its design limits its affinity for IGF-binding proteins (IGFBPs), which normally restrict IGF-1's activity