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In animal studies, L-carnitine has shown promise in reducing fatigue and improving psychomotor function, likely due to its role in promoting fatty acid metabolism and boosting energy levels [48]
Without adequate GSH, low NADPH results in increased reactive oxygen species (ROS)
Accumulation of toxins in the mitochondria might damage and affect the same
It also assists in maintaining healthy liver detoxification pathways and cellular protection
Positive action of high doses of thiamine under metabolic perturbations including surgeries (48, 115, 149, 153155) suggest that cellular protection and/or repair requiring cell differentiation, increase demand of thiamine
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