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Generation of GM mice with the MLC enhancer incorporated in site 2 To extend our study from cell lines to a whole animal context, we generated genetically modified mice by injecting Cas9 mRNA, sgRNA targeting site 2 and the circular donor plasmid into mouse zygotes (Table 1)

Sleep deprivation disrupts hormones that regulate appetite (increasing ghrelin and decreasing leptin) and impairs glucose metabolism

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We use the abbreviations o = outside, b = blood, c = cytosol, so, for example, V oCysb is the transport of cysteine from the outside into the blood

A decrease in progesterone levels may disrupt the balance between estrogen and progesterone, promoting the growth and proliferation of endometriotic lesions 90