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GLP-1 medications like Ozempic, Wegovy, and Mounjaro may cause facial changes due to rapid weight loss, leading to a noticeable reduction in facial fat
and the PEGylated agonist NLY01, which on this account does not effectively reach the brain despite being engineered for penetrance, was negative in a Phase 2 Parkinsons trial [12,13]
10.3390/ijms23031546 65 JiL.ZhangY.LiY.SongL.ZhangT.DuC.et al (2025)
This substantial reduction in food noise with GLP1 RA drugs, when combined with behavioral treatment, is in line with previous anecdotal findings and may serve as an early indicator of treatment response. The team says this finding is important because food noise can make healthy behaviors much harder to maintain over time
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